Monday, March 23, 2009

Doctors increasingly close doors to drug reps, while pharma cuts ranks

Doctors increasingly close doors to drug reps, while pharma cuts ranks

Many physicians see detailers only with scheduled appointments. Drugmakers are responding to hard times with layoffs and a shift toward online marketing.

By Kevin B. O'Reilly (AMNews staff)
Posted March 23, 2009.

Source: http://www.ama-assn.org/amednews/2009/03/23/prl10323.htm#s1

________________________________

The relationship between doctors and drug reps may never be the same again.

Pharmaceutical companies -- battered by a sluggish drug pipeline, the looming loss of blockbuster patented drugs, an economy in recession and scrutiny of their relationships with physicians -- are re-examining the value of sending drug reps into doctors' offices. Detailers are struggling to grab a shrinking slice of physicians' valuable time and attention while adjusting to new drug industry rules banning freebies such as pens and notepads.

At its peak in 2007, the American pharmaceutical industry fielded 102,000 sales reps, said Chris Wright, managing principal for the consulting firm ZS Associates' U.S. Pharmaceuticals Practice. Drugmakers have slashed the number to 92,000 since then, and ZS projects the number will fall to 75,000 by 2012 at the latest, saving the industry $3.6 billion.

Pharma's return on investment in its sales force has plummeted. For every 100 reps who visit a practice, 37 place their products in the office's sample cabinet, and only 20 speak to a physician in person, said the New York-based consulting group TNS Healthcare. Profit per drug rep visit fell 23% from 2004 to 2005, said a February PricewaterhouseCoopers report on pharma's future.

"The old sales model is broken now, and who knows how it will look in the future," said Peter H. Nalen, president of Compass Healthcare Communications, an online drug marketer in Princeton, N.J. "What's happening is that pharmaceutical companies are realizing there are other ways to reach the doctor instead of banging on the door of the doctor who just doesn't want to talk to you."

1 in 4 doctors works in a practice that refuses to see drug reps.

The time squeeze and the new drug industry rules are "changing the landscape quite dramatically," Nalen said. Another troubling sign for drugmakers: More than a third of medical schools require drug reps to have appointments before seeing physicians or residents, according to the American Medical Student Assn.'s 2008 PharmFree Scorecard. The Assn. of American Medical Colleges recommended the by-appointment-only policy in May 2008.

While most physicians still have positive views of detailers and drugmakers, those sentiments are cooling.

About one in four physicians works in a practice that refuses to see drug reps. Of doctors who do see reps, about 40% will meet with detailers only with scheduled appointments. The by-appointment-only figure jumped 23% during the last six months of 2008, according to a survey of more than 227,000 medical practices representing 640,000 physicians that was released in February.

The survey, conducted by the doctor-profiling firm SK&A Information Services Inc., did not seek to determine why some physicians are giving drug reps the cold shoulder. But physicians and pharmaceutical industry consultants say doctors have felt besieged by the number of reps visiting their offices and taking up precious time in an era of declining payment.

Last year saw a slight drop in a measure of the quality of detailers' relationships with doctors, based on a TNS survey of more than 1,500 doctors. And negative word-of-mouth about pharma rose sharply among physicians -- this so-called market-resistance index jumped 62% in the last year, TNS said.

Controversies over the drugs marketed as Vioxx (rofecoxib), Avandia (rosiglitazone) and Vytorin (ezetimbe and simvastatin) appear to be making doctors more skeptical of drugmakers as an information source, said Jerome L. Avorn, MD, professor of medicine at Harvard Medical School in Massachusetts.

"Doctors are increasingly concerned that the sales pitches from drug reps are not giving them the full story," said Dr. Avorn, author of the 2004 book, Powerful Medicines: The Benefits, Risks, and Costs of Prescription Drugs.

Ken Johnson, senior vice president at the Pharmaceutical Research and Manufacturers of America, said in a statement that detailing visits are good for doctors and patients. "Interactions between physicians and pharmaceutical company representatives benefit patient care through the exchange of information about new medicines, new uses of medicines, the latest clinical data, appropriate dosing and emerging safety issues."


Interacting with detailers


For every physician, it seems, there is a different way to handle drug reps.

Charles E. Crutchfield III, MD, is a dermatologist with a high-volume practice in Eagan, Minn., a suburb of Minneapolis. Though five to 10 reps visit his office daily, he strictly limits detailers to one five-minute session a week and requires that the rep provide lunch for his staff.

More than a third of med schools require drug reps to make appointments.

"The reps know they are not allowed to disturb me when I am seeing patients," Dr. Crutchfield said. "If they do bring samples, I have a nurse who will bring the pad back to me so I can sign it. I will not see or talk to reps when I'm in clinic."

Ari Silver-Isenstadt, MD, persuaded the four other doctors and officestaff in his Baltimore pediatrics practice to adopt, in January 2008, a "no soliciting" policy for drug reps. Dr. Silver-Isenstadt is a member of the National Physicians Alliance, whose Unbranded Doctor Campaign urges physicians to refuse industry gifts and stop seeing drug reps.

Despite the new survey figures showing that doctors are cooling to drug reps, he said physicians should be more aggressively addressing the conflict of interest detailers pose.

"More than half of us doctors still just have a feeding frenzy of reps in our offices," he said. "We should be ashamed of ourselves for allowing such an intertwining of our patients' best interests with the convenience and niceties of drug reps."

Not all doctors share Dr. Silver-Isenstadt's hard-line view.

Most are simply pressed for time. Drug companies are trying to reach out to doctors via the Web, experts said. About 45,000 doctors meet with detailers using online video, and 300,000 physicians say they are open to doing so, said a September 2008 study from Manhattan Research, a drug marketing research firm.

Visits by drug reps will not disappear entirely, experts said. Rather, the sales force that survives the layoffs will be better trained and have a greater depth of clinical and scientific knowledge.

Detailers "reach the customer in a way that other promotional techniques do not," said Wright, of the ZS Associates consulting firm. "And for many of these doctors, the choices they make about what to prescribe are worth a considerable amount of money.

"When that's on the table, it makes sense to send a highly trained person to make sure the doctor knows about the medicine before making those choices."

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Friday, March 20, 2009

Darwin and the History of Pharma

Darwin and the History of Pharma

Source:
http://social.eyeforpharma.com/blogs/stadkins/darwin-and-history-pharma

March 20, 2009

By Stewart Adkins

Allusions to Darwin can be fun and I suppose corporate archaeologists of
the next geological era will happily sift through the promotional
detritus of yesteryear (Lucites, mugs, pens etc) as the only remaining
fossil evidence of the existence of the pharmaceutical dinosaurs that
are already extinct - AH Robins, Fisons, Syntex, Burroughs Wellcome,
Marion Labs, Pharmacia, Upjohn, to name a few.

However, those fossilized remains will give few if any clues as to the
reasons for the extinction of their originators. For the industry has
not been hit with the pharmaceutical equivalent of a large meteor that
blotted out the sun for millennia; rather there has been a series of
subtle changes in the environment that have been well flagged over the
years.

There are two fundamental problems for the industry to deal with;
firstly, the lead time for new drug discovery through to
commercialization is much longer than the duration of most political or
regulatory regimes, with the corollary that industry has to take a
thoughtful and strategic view as to the long term health needs of
society in order to direct its R&D without concerns that the environment
will shift in the interim.

Secondly, the healthcare needs of society do not revolve around the
consumption of medicines alone; any consideration of how to help solve a
healthcare problem needs to embrace a more holistic approach to
prevention and treatment involving all relevant stakeholders - patients,
physicians, providers of care or medical interventions and payors.

This is clearly an ultra-simplistic view but defining the problem in
such basic terms can be helpful in allowing a view of the wood rather
than just the trees. Extinction may be too harsh a word to apply to
companies who were the subject of hostile takeovers or reluctant
(sometimes willing) mergers since some of these could probably have
survived alone.

However, very few companies seem to have acknowledged and planned for
the fundamental problems identified above; an intense focus on line
extensions, lifestyle diseases and the medicalisation of life's usual
travails at the expense of more basic understanding has left companies
with portfolios struggling to demonstrate value in a society with little
disposable income.

Meanwhile, placing the product at the centre of all sales and marketing
efforts rather than the patient has channelled too many financial
resources in the wrong direction and resulted in corporate
infrastructures that are structurally misaligned with society's needs.
It is not too late to change, for those with vision and the financial
resources to manage through the transition but as in the past, those who
struggle to adapt or don't see the need to adapt may face extinction,
through hostile takeovers or reluctant mergers. Happy Birthday Darwin.

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Disease-Centric Communities Thrive, But Ad Opportunity is Elusive

Disease-Centric Communities Thrive, But Ad Opportunity is Elusive

By Virginia Citrano <http://www.clickz.com/3630351> , ClickZ, Mar 20,
2009

Though doctors are now showing a high degree of interest in online
social networking, consumers with illnesses were there well before them
and their fast-growing communities may present an opportunity for the
medical and pharmaceutical industries.

Membership in TuDiabetes <http://tudiabetes.com/> , a network for
English-speaking diabetes patients, is now nearing 8,000 and growing at
10 percent to 15 percent a month. EsTuDiabetes
<http://estudiabetes.com/> , its sister site for Spanish speakers, is
growing at an even faster pace and both sites have a global following.

"It definitely came as a very pleasant surprise," says the sites'
founder, Manny Hernandez, of their growth. "Because I am very open about
[my diabetes], I was surprised to hear people say this is the first time
I've had the chance to chat with people about diabetes."

And they are chatting in many places besides the TuDiabetes sites, which
was started in 2007. DailyStrength has separate communities for type 1
and type 2 diabetes, and, last November, the Juvenile Diabetes Research
Foundation launched its community, Juvenation. The sites come on top of
dozens of well-trafficked blogs, like DiabetesMine and portals like
Diabetes Daily and the doctor-focused DiabetesConnect. There are also
community-like sites created by pharmaceutical companies for their
products, like the one for Sanofi-Aventis' slow-release insulin shot
Lantus. The site was ranked highest for satisfaction in a new
ManhattanResearch survey of ePharma consumers.

The corporate sites are, of regulatory necessity, less freewheeling than
their independent counterparts. Pharmaceutical companies are required by
law in the U.S. to report to the U.S. Food and Drug Administration any
problems caused by their drugs and kvetching is pretty much a staple of
user-generated content on any social networking site. But
ManhattanResearch notes that corporate sites can add rich features to
their sites that make them highly attractive to consumers, such as
instructional guides and videos, money-saving coupons and access to
customer-service representatives. (The "ePharma" report looked beyond
diabetes to assess visitation and satisfaction on more than 40 company
sites and more than 50 unbranded sites.)

TuDiabetes is arguably the most tech-savvy of the independent diabetes
communities: Hernandez built it on social networking platform Ning, the
company at which he worked before starting TuDiabetes. His new venture
has just two full-time employees, but relies on a network of member
volunteers to keep the discussions free of spammers and welcome new
members. The volunteers read every new sign-up and send a personal
e-mail to help the newcomer find the discussions most appropriate to
their diagnosis.

The Venezuela-born Hernandez, who is fluent in both English and Spanish,
started his community in the former but quickly realized that there was
as great a demand for information in Spanish-speaking areas of the
world. EsTuDiabetes now has a following not only in Venezuela, but in
Mexico, Spain, Ecuador, Chile, Costa Rica and among Latin Americans in
the U.S.

Despite the seemingly crowded landscape, Hernandez, who was diagnosed
with diabetes in 2002, says his greatest competitors are "ignorance and
unawareness."

"Putting together all the online communities that serve diabetes
patients, we're probably not even getting to 100,000 people," said
Hernandez. "Yet there are 25 million diabetics in the U.S and 250
million worldwide." The World Health Organization expects the number of
diabetics to reach 366 million by 2030.

With statistics like those, it's easy to understand the strong interest
in branded and unbranded drug and disease communities evidenced in the
ManhattanResearch survey. And many of the unbranded sites already accept
pharma and general consumer advertising. But like their counterparts in
the broader social networking space, they are wary of intrusions.

"We don't want people joining just to promote a product," said
Hernandez. "We feel it is important to keep ads established as such and
separate from conversations. Those have to stay between patients because
that is how the site provides the most authenticity."

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Thursday, March 19, 2009

A glimpse into the surgery room online

Source: http://hippocratech.org (Hippocratech)

Who hasn’t watched the latest Grey’s Anatomy as medical residents fight tooth and nail to have a glimpse of cardiovascular surgeon Erica Hahn performing a double valve replacement on the father of medicine, Wiiliam Tapley? So little space in the operating room, so little opportunity for future surgeons to improve their cutting operating skills.

SurgyTec is an initiative develped by plastic surgeon Stevens MD, PhD to solve that. The site’s goal is to improve and share surgery techniques in order to improve one another’s skills. Physicians can now watch videos from ACL reconstruction to performing a midface lift.

So if you need a last minute refresher course on the use of robotic total mesorectal excision for the treatment of rectal cancer, SurgyTec is the place to visit!

Original blog:

http://hippocratech.org/2008/05/22/a-glimpse-into-the-surgery-room-online/

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RealSelf: Cosmetic Surgery Community Online (RealSelf.com)

According to The American Society for Aesthetic Plastic Surgery (ASAPS) Cosmetic Surgery Statistics:

  • Nearly 11.7 million surgical and non-surgical cosmetic procedures performed in the United States in 2007
  • Top five non-surgical cosmetic procedures in 2007: Botox Injection (2,775,176 procedures); hyaluronic acid (1,448,716 procedures); laser hair removal (1,412,657 procedures); microdermabrasion (829,658 procedures); and IPL laser treatment (647,707 procedures)
  • Top five surgical procedures for women: breast augmentation, liposuction, eyelid surgery, abdominoplasty and breast reduction
  • Top five surgical procedures for men: liposuction, eyelid, surgery, rhinoplasty, breast reduction to treat enlarged male breasts, and hair transplantation

With Americans spending just under 13.2 billion on cosmetic procedures last year (ASPS), it was inevitable that a health-community site would sprout up centered around beauty through cosmetic enhancement.

RealSelf was developed by Tom Seery (who used to work at Expedia) in 2006 after his wife complained that it was easier to find reviews on hotels than laser surgery. Backed by investors with impressive backgrounds: Rich Barton (Chairman and Chief Executive Officer of Zillow), Nick Hanauer, and Bill Gossman, the site is making a splash in the cosmetic industry.

RealSelf contains reviews by patients who has undergone cosmetic surgery. What makes the site so addictive are the stories told by patients complete with extremely vivid pictures. Besides patients’ contribution, the site has board-certified cosmetic surgeons answering questions, which further adds to the site’s credibility. This is a great site for those considering an enhancement to their beauty and need information from people who have gone through the surgery.

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Ad Agency Hill Holiday dumps website for "all-blog format"

Ad Agency Hill Holiday dumps website for “all-blog format”

source: Fuel Lines (http://fuelingnewbusiness.com)

An ad agency has dumped its website for a blog. But not just any ad agency, one of the best known agency’s in the country, Hill Holiday, has done it. They now have an “all-blog format.” Could this be a trend, perhaps the wave of the future. I predict that it is.

Complete Story:
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Harvard Economist Blames Twitter for Down Economy

Harvard Economist Blames Twitter for Down Economy

A new study suggests that Twitter is the root cause of the current
economic malaise. Policy experts predict a Twitter moratorium may be
declared for Summer 2009 as part of an effort to stimulate economic
production and reverse GDP declines.

Read more:

http://www.gaebler.com/Economist-Blames-Twitter-for-Down-Economy.htm

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Facebook's New Layout: A Detailed Guide

For all those frustrated with the new facebook layout (and apparently many of you are), here is a great guide provided by a company called The Advanced Guard (www.theadvancedguard.com).  Someone I was following tweeted his frustration with the new layout by comparing it to "moving furniture in a blind person's house".  So appropriate.  Well, this guide does an outstanding job of laying out a map.  Enjoy.
 

Below is a description from Noovo.com:

OVERVIEW

With the recent update to Facebook Pages, many brands and businesses will be left wondering how they can best take advantage of this upgrade. The Advance Guard has collected some ideas and tips into a white paper that can now be freely downloaded and shared under a Creative Commons license.

HIGHLIGHTS

  • Optimizing Tabs for maximum effectiveness.
  • Strategies to increase activity on your Wall and Stream .
  • Choosing the right Applications to install.
  • Creating custom landing zones for newcomers.
  • Increasing viral spread of your brand, and things to avoid
  • Recruiting new Fans and engaging with existing ones.

ABOUT ADVANCE GUARD

The Advance Guard is a new media consultancy that creates radical marketing programs using disruptive technologies, community platforms and social media. Our clients include American Eagle Outfitters, Verizon FiOS, The Coca Cola Company, HBO, and Warner Brothers.

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Another Reason to be Skeptical of "Analysts"

The Times runs a piece today citing a media analyst at Sanford Bernstein claiming:

...monetizing Twitter “would be difficult at best and likely unsuccessful.” People who sign up for free services tend to resent a company for trying to wring revenue from the business later. Subscription fees are out of the question, they said, and advertising-based revenues don’t seem to have yielded enough cash flow to make a Web 2.0 property viable.

I agree about one thing - building ad platforms like Tweetsense will be difficult. But nothing valuable is ever easy. Adwords was not easy. Overture was not easy. What Facebook is building is not easy. And TweetSense won't be easy.

But that's the point, isn't it? If it was easy, everyone would do it.

To be entirely clear, Twitter has at least three major potential revenue streams.

1. Tweetsense - AdWords and AdSense like platform for Twitter. This has major scale potential.

2. Branded licensing. This is stuff like Stocktwits, where Twitter could promote and perhaps gets licensing fees.

3. SMS/carriers - deals with carriers to split revenue driven by mobile tweeting.

And there are plenty more.

Analysts who write stuff like this are clearly not thinking very hard about the potential of services like Twitter, nor do they understand the appetite for risk the venture capitalists backing such ideas have. Check this quote:

"Whoever buys Twitter, they wrote, “will likely have to operate it at a loss in perpetuity, or until the next cool Web 2.0 social networking concept comes along and Twitter tweets no more.”

Utterly ridiculous on so many fronts it's hard for me to summon the energy to refute it. The idea of the tweet as the query, the idea of brands wanting to have a commercial "response" to searches (and tweets) on Twitter, these are not small ideas. The idea of real time search, conversational and social search, real time "AdWords" - these are not minor new wrinkles. They are here to stay. Twitter is a very promising service directly in the center of these trends, trends the "analysts" at Sanford Bernstein clearly do not grasp.

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Internet is primary means of support for people caring for elderly parents

Internet is primary means of support for people caring for elderly parents

More than 65% of people caring for elderly parents use the Internet as their primary means of support and encouragement, according to a survey from AgingCare.com. Family caregivers use online forums and message boards to connect with other caregivers. According to the survey, 53% of caregivers provide care for 40 or more hours per week, while 36% get a break of less than 5 hours a week. Yet they manage to squeeze in time online. Most users post on AgingCare.com very late at night or early in the morning, says the site.

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Wednesday, March 18, 2009

Chugai Discloses Side Effects of Roche RA Drug: 15 Deaths Reported

TOKYO -- Roche Holding AG's new rheumatoid arthritis treatment might have been a causal factor in the death of 15 out of nearly 5,000 people who took the drug in Japan, with serious side effects such as pneumonia and severe fever detected in over 200 people, Roche's Japanese partner said Wednesday.

The drug, Actemra, is one of Roche's most important new products in development.

A spokesman for Chugai Pharmaceutical Co., which is 60%-owned by Roche, confirmed Japanese media reports on a study into nearly 5,000 users of Actemra. The spokesman said the company "can't deny" that there may have been "a causal relationship" between the drug and the deaths. He said the company will provide more information so that doctors can have a better understanding of possible side effects.

The study was conducted by the Japanese company as part of requirements imposed by Japan's Ministry of Health, Labor and Welfare when the drug was approved.

Roche said that the death rates among patients taking Actemra were similar to those of rheumatoid-arthritis patient populations generally, and also similar to those of patients taking other biological drugs for rheumatoid arthritis. "We don't see a deviation here that gives us reason for concern," a Roche spokeswoman said.

A pharmaceutical analyst for Morgan Stanley said the death rate of roughly 0.3% of Actemra users is similar to the death rate of Enbrel, an "established RA therapy." Morgan Stanley said it continues to forecast peak Actemra sales of 1.65 billion Swiss francs ($1.39 billion) despite the Japanese reports.

Actemra is approved for rheumatoid arthritis in Japan and the European Union but not yet in the U.S., where the Food and Drug Administration has asked the company for a new animal trial of the drug and other information. The biological drug treats rheumatoid arthritis in a new way -- by blocking a protein in the body called IL-6, which plays a role in inflammation.

The Chugai spokesman said his company expects sales of 15.5 billion yen ($157.3 million) for 2009 from the drug, which was first approved in April 2005 in Japan as an agent to treat enlarged lymph nodes and then in April last year to treat rheumatoid arthritis.

Japan's health ministry had requested a study of all Japanese patients who had taken Actemra and Chugai will continue the study until the ministry obtains enough data.

According to the interim results of the study into 4,915 cases, conducted through doctors who prescribed the drug, heavy side effects such as severe fever, pneumonia and phlegmon were found in 221 cases, the Chugai spokesman said.

—Jeanne Whalen contributed to this article
 
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Cephalon's Provigil may be addictive-US study

Cephalon's Provigil may be addictive-US study

Source: http://www.reuters.com/article/americasRegulatoryNews/idUSN1729677120090317?sp=true

By Julie Steenhuysen

* Addictive signature in Cephalon narcolepsy drug

* Provigil boosts dopamine levels in brain

CHICAGO, March 17 (Reuters) - Provigil, a narcolepsy drug increasingly used by healthy people to boost brain performance, may be addictive in vulnerable people and should be monitored, U.S. drug abuse experts said on Tuesday.

A pilot study on 10 healthy men found that at normal doses, the Cephalon Inc (CEPH.O) drug known generically as modafinil increases levels of the reward chemical dopamine in the same part of the brain that becomes active with other drugs of abuse.

"It has the signature that it could potentially be addictive," said Dr. Nora Volkow, director of the National Institute on Drug Abuse, whose study appears in the Journal of the American Medical Association.

"Studies have shown consistently that all of the drugs of abuse ... have a common effect of increasing dopamine in this area, in the nucleus accumbens," Volkow said in a telephone interview.

"That is believed to be crucial for their reinforcing effect and ultimately their underlying potential for producing addiction."

Cephalon said in a statement the findings are consistent with what is already known about the drug, noting that it is classified as a schedule IV medication by the Drug Enforcement Administration, meaning it has some potential for abuse and dependence.

While officially approved only for excess sleepiness associated with narcolepsy, sleep apnea, and shift work disorder, Provigil is also used for weight loss, attention deficit hyperactivity disorder, fatigue and depression. Last year, it had sales of more than $852 million.

But its increasing use on college campuses to improve cognitive performance led Volkow to look more closely at the drug's potential for addiction and abuse.

"The main problems that we see are not the people who are properly prescribed the medication, but individuals who may be misusing and abusing the medication," Volkow said.

BRAIN-BOOSTER

In December, Volkow said recent surveys on college campuses suggest drugs such as Novartis' Ritalin (NOVN.VX), or methylphenidate, and Provigil are being used by students, professors and others as a brain-boosting drug.

Volkow said it had not been clear before the study whether Provigil increases dopamine -- the same chemical reward system in the human brain as other drugs of abuse.

The researchers used positron emission tomography and a well-known drug of addiction to trace the activity of modafinil in 10 healthy men between the ages of 23 and 46.

Volkow said the preliminary findings show modafinil activates the dopamine reward system in the brain. "That potential had been dismissed for modafinil because it was believed it had no significant dopinergic effects. Our findings question that," she said.

"The message for individuals who are taking this medication who want cognitive enhancement is that its use could result in very serious cognitive effects, including addiction."

Volkow said her agency plans to begin monitoring use of modafinil in its regular surveys of potential drugs of abuse.

(Editing by Maggie Fox and Sandra Maler)

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Botox v. Reloxin: Market Share Battle May Revive DTC Spending Late in 2009

Botox v. Reloxin: Market Share Battle May Revive DTC Spending Late in 2009
 
Source: Pharma Marketing Blog (John Mack)
 
you thought the DTC advertising sleep aid (Lunesta v. AmbienCR v. Rozerem) advertising war was excessive, wait until Reloxin is approved for marketing by the FDA, which may happen during the second half of this year according to Bloomberg.com (see "Medicis's Reloxin May Vie With Botox in U.S. to Clear Wrinkles").

“The results of the study [published in the March/April issue of Archives of Facial Plastic Surgery] show that it’s as good as Botox," Ronald Moy, the lead author of the study and a professor in the medical school at the University of California, Los Angeles, in a March 13 telephone interview. "The side effects are the same as Botox."
Click link below to continue:
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Tuesday, March 17, 2009

Tit-for-Tat Tithe on Pharma Marketing. How It Can Work

Tuesday, March 17, 2009

Tit-for-Tat Tithe on Pharma Marketing. How It Can Work.

Source: Pharma Marketing Blog (John Mack)

A few weeks ago, Fabio Gratton, Co-founder nd Chief Innovation Officer at Ignite Health and ePharma Pioneer Club™ member, was a guest on my Pharma Marketing Talk live streaming audio/chat show where he enlightened us about "How To Measure Social Network Communications Success" (see PMT Show #69).

During that interview, Fabio threw out a half-baked idea idea intended to help pharmaceutical companies effectively use social media networks by limiting the regulatory risks in exchange for setting aside 10% of their resources (online ad spend? total marketing? profits?) to promote general health and well being.

For the complete story, click below:
http://pharmamkting.blogspot.com/2009/03/tit-for-tat-tithe-on-pharma-marketing.html

 
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FDA Widgets: How About One for Adverse Event Reporting?

Tuesday, March 17, 2009

FDA Widgets: How About One for Adverse Event Reporting?

source: Pharma Marketing Blog (John Mack)
 http://bit.ly/ZYvzy

Fabio Gratton is at it again! He has started a poll, which asks "To all pharma marketers: A universal FDA Adverse Event widget required by all pharma websites (brand, disease, social) would be effective?"

I assume he is following up on the "Tit-for-Tat Tithe" idea and that the widget he is proposing would allow visitors to pharma websites to easily report adverse events DIRECTLY to the FDA. This would lift the burden from pharmaceutical companies to track, investigate and report the adverse events themselves and free them up to focus on using social media sites for marketing purposes.

Sounds like a good idea. What do you think? Take Fabio's poll here.

Meanwhile, here are a few widgets developed by third parties that push out FDA information on drug safety topics. They are not interactive in the sense that you can enter information into them.

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Monday, March 16, 2009

twtpoll ::To all pharma marketers: A universal FDA Adverse Event widget required by all pharma websites (brand, disease, social) would be effective?

twtpoll ::To all pharma marketers: A universal FDA Adverse Event widget required by all pharma websites (brand, disease, social) would be effective?

Posted using ShareThis

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Pink Tank Launches New Website: KNOWHER.COM

Pink Tank Launches New Website

Marketing to Women Division of GSW Worldwide Introduces ww.Knowher.com

COLUMBUS, Ohio March 10, 2009- Pink Tank, a division of GSW Worldwide,
an inVentiv Health company (NASDAQ: VTIV), recently launched a new web
site at www.knowher.com.

Pink Tank is a full-service consultancy, specializing in women and
health that helps marketers connect with the female influencers in
healthcare, whether they are healthcare professionals, patients,
caregivers or consumers. The Pink Tank team consists of experienced
marketers with a unique combination of marketing to women experience and
professional healthcare expertise.

The fun and easy-to-use site (www.knowher.com) reflects Pink Tank's
specialized offerings and ability to find the affinity point that
resonates with a woman and her healthcare provider, while also providing
information about strategic consulting services that recognize future
trends and emerging brand opportunities for clients who want to reach
women consumers.

"Over the past two years, Pink Tank has generated so much interest we
wanted to make it easier for people to find out what we are about," said
Marcee Nelson, founder and president of Pink Tank. "Previously,
information about Pink Tank was found only through GSW Worldwide's
website so it seemed like the right time for us to create knowher.com.
The site will allow us to expand our reach and give people a chance to
explore in more detail how our unique blend of expertise might help them
with their marketing challenges," says Nelson.

The site explains how Pink Tank's combination of marketing to women
experience and health care expertise makes the group uniquely equipped
to bring a health lens to consumer products or the ability to impact
both sides of the physician/patient conversation in the pharmaceutical
space. There is information about how Pink Tank can help streamline the
strategic process with proprietary insight mining methods and strategy
tools like Conversation Mapping(tm) and Empathology(tm). Knowher.com
also highlights Pink Panels(tm) and Pink Rooms(tm), tailored qualitative
research techniques that help uncover the hardwiring that drives
behavior and can measure an idea's "shareworthiness" among women.

"Pink Tank fills a gap because healthcare is a world of practical
benefits but the way in which women make health decisions is anything
but practical," explains Nelson. "We hope the site reflects various ways
in which our team can help create a lasting, impactful brand experience
for all stakeholders involved in healthcare decision making."


About Pink Tank

Pink Tank is a full service consultancy specializing in women and health
strategy and creative. Pink Tank generates media-neutral big ideas that
come from a unique combination of consumer and professional healthcare
brand experience for a wide variety of products including prescription,
over-the-counter, health & wellness and better-for-you products.

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Sunday, March 15, 2009

Another Lunch with Big Pharma-Novartis Has Its Hands Full

Another Lunch with Big Pharma—Novartis Has Its Hands Full

December 13, 2008

By Barbara Brenner, Executive Director, Breast Cancer Action

source: http://bcaction.org/index.php?page=third-day-in-san-antonio

Today’s lunch time entertainment was a presentation by Novartis to promote Zometa. The program was called “Metastatic Breast Cancer: Why are my bones important?” The company rep started by telling us that this drug is doing great things for women, but that there are still lots of people who are untreated but who need to be. She expressed the hope that we would obtain useful information for the patients we talk to, or, at least, to remember to call Novartis if we have questions.

The first speaker was Marcia Strassman, an actress (Welcome Back Kotter) who was diagnosed with bone mets at her initial diagnoses. She is now partnered with Novartis (and has a Facebook page) to offer support and information to other people with breast cancer about the importance of following prescribed treatment. In the case of Zometa, that's an infusion every 28 days. Marcia was diagnosed after she found what she called a mound, even though she had been getting regular mammograms and had had one 7 months before her diagnosis. Fortunately for her, she had been involved in a benefit to raise money for cancer research for years, and had access to the best doctors. Unfortunately, a scan revealed bone mets, and we she was placed immediately on Arimidex and Zometa. She said she had an allergic reaction to Arimidex, so was switched to Femara. She was very thankful for the drug, which happens also to be made by Novartis. She wanted us to know that most of her activities have not been affected—she’s living her life, and doing her treatments. In fact, she told the group that she was able to get her Zometa when she traveled.

Turned out when she was asked about getting Zometa on the road that Marcia has a health insurance plan that lets her do things that an HMO or an uninsured person can’t do. Great representative for what happens to people with breast cancer, no?

The next two presenters were both doctors—Adam Brufsky and Hope Rugo. They talked about the importance of bone health, and the powerful effect of Zometa. Neither of them disclosed how much Novartis pays them for their work on behalf of the company. Brufsky wanted us to know that great progress has been made in breast cancer, and that the majority of women diagnosed now will be cured of their disease. He promised that in the next few years we’ll see phenomenal progress. (Where have we heard this before?) And he credited the advocates in the room for raising money for research, and urged us to keep doing that. (I can’t be sure, but I’m betting that most of the women in the room work for organizations that don’t raise money for research.)

Hope Rugo framed her presentation interestingly, pointing out that she would talk about what happens in the real world with Zometa, and noting that clinical trails are, as she put it “a little contrived.” She spoke glowingly of the advantages of Zometa, and stressed at some length how rare osteonecrosis of the jaw is as a side effect.

Then it was question time, and that got interesting. Questions could be posed in writing or verbally. Some questions were about treatment issues. I asked about the fact that the company, which makes all these drugs that are addressing cancer like Zometa and Femara (an aromatase inhibitor), also makes the herbicide atrazine, which stimulates aromatase. There was a question about Evista (raloxifene) for breast cancer, which Hope Rugo handled quite well, pointing out that the drug is not a breast cancer drug, but that she prefers it for “prevention.”

Roberta Gelb, an activist who works with several organizations, pointed out to Dr. Brufsky that, despite his urging, none of the advocates in the room would tell the patients they work with to live their lives and leave their breast cancer to their oncologists. After a defensive response from the doctor, the session ended.

The activists with whom I spoke after this lunch were deeply offended by the presentation. They felt patronized and angry. It’s clear that Novartis did not know who was in the room—very well informed, passionate, and smart advocates and activists who need and demand real information, not pablum sugar-coated by a drug company.

 
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Friday, March 13, 2009

Social networking docs write more scripts: eMarketing - Medical Marketing and Media

http://www.mmm-online.com/Social-networking-docs-write-more-scripts-eMarketing/article/128698/

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MediaPost Publications Twitter Driving Traffic To Social, Entertainment Sites 03/13/2009

http://www.mediapost.com/publications/?fa=Articles.showArticle&art_aid=102076

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Online coupon volume and redemption booms in 2008

Online coupon volume and redemption booms in 2008

The amount of online coupons boomed in 2008, with redemption rates far exceeding those of print coupons, according to an eMarketer report. Coupon processing company Inmar said 13% of online coupons were redeemed last year, whereas just 1% of print coupons were redeemed. Since 2007's previous high, online coupons have experienced a 140% growth rate. Currently, online coupons represent just 1% of the 2.6 billion coupons offered in the United States each year. Most consumers clip their coupons from newspapers, receipts, and other paper sources, with less than 30% finding coupons online, according to comScore data.

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Pharma connects with patients, doctors via social networking sites

Pharma connects with patients, doctors via social networking sites

Pharma companies have started using social networking sites to recruit clinical trial patients, according to a Newsweek article. Sites that are specifically geared toward people with serious or chronic diseases give pharma access to engaged patients with defined medical conditions. Recruiting patients via social networking sites may help clinical trials attract the amount of people they need-about 80% of the 50,000 clinical trials under way in the United States are delayed at least one month due to low enrollment. Pharma is reaching out to doctors through social networking sites as well. Some companies are buying access to physician-specific sites such as Sermo and WebMD's Medscape Physician Connect and are given access to physicians' online discussions.

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Growing numbers of African-Americans use the Internet regularly

Growing numbers of African-Americans use the Internet regularly

The racial digital divide is shortening, with an increasing number of African-Americans going online regularly, according to an eMarketer report. The analytics company estimates that more than 19 million African-Americans, or nearly half of the African-American population, uses the Internet at least once per month. It projects that 56% will be online in four years. This is good news for companies, since the African-American population has strong spending power, estimated at $913 billion in 2008 by the Selig Center for Economic Growth. However, African-Americans made fewer online purchases than other minority groups in 2007, according to The Media Audit. Just 20% had purchased five or more items online that year, and less than 11% bought 12 or more items online.

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Wednesday, March 11, 2009

European Pharma Moves on Social and Digital Media

European Pharma Moves on Social and Digital Media

Source: http://bit.ly/C6uwK

In nearly any conversation about digital and social media on a global scale, one is bound to hear the refrain that European pharmaceutical companies have even more inhibitions than their American counterparts because of the existence of DTC in the US and because they are restricted in their communications with patients in Europe.

Defying gravity, if not convention, Roche, headquartered in Basel Switzerland, today issued an elegant multimedia release on its latest study results involving Herceptin.   First note the slide comparisons of cells near the headline, which are completely enlargeable. But then off to the right, there is not only a video that explains the significance of the findings, but a menu list of other videos one can watch.  There is also, in the upper left hand corner, a menu of offerings to get further communications from Roche, including podcast access and subscription to their RSS feed.  Believe it or not, some large companies still are not using RSS feeds.  A link is also provided if the reader wants to obtain video clips and there are links to document the company's work in oncology.  

This type of release is significant because it offers so much.  It is not just news about the product, it is a virtual Roche oncology library, allowing a reader to only read about the study, or to find further useful background information should it be desirable, without making the reader go hunt for it.  In other words, it accomplishes a one-stop shop for nearly any kind of reader.  

Nice work Basel.

Forgive the lack of cropping on the screen shot - Microsoft's changes to Powerpoint 2007 are completely indecipherable in a most unyielding sense.   
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Online Alcohol Intervention and Prevention Programs

Online Alcohol Intervention and Prevention Programs

by Katie Howard

Learning Objectives

This Public Health Informatics Wiki will help readers:
  1. Provide a general overview of alcohol intervention web-based programs.
  2. Identify the types of alcohol prevention and intervention programs that can be best conducted online.
  3. Identify key components of online alcohol programs.
  4. List at least three positives and three negative aspects of alcohol intervention web-based programs.

Web-based Alcohol Abuse Prevention Programs

Web-based interventions for primary and secondary prevention of alcohol abuse have become increasingly popular. These websites tend to target either high-risk groups or those who abuse alcohol. Interventions are not usually designed to address issues surrounding alcoholism or alcohol addiction since this diagnosis tends to have different and more severe consequences surrounding physical and psychosocial health (Moyer, Finney, Swearingen, & Vergun, 2001). Web-based interventions can help to identify behavioral patterns that lead to or cause alcohol abuse. These interventions are usually for people who are entering college as undergraduates or for people who have been identified as alcohol abusers.

Alcohol Abuse and College Students

College students have been identified as an at-risk group for binge drinking and alcohol abuse. Hingson, Heeren, Winter, and Wechsler (2005) randomly sampled thousands of college students to determine typical drinking behavior. The study used the typical definition of binge drinking which is five or more drinks for men and four or more drinks for women in a single drinking session. They found that 23 percent of students had binge drank three or more times in the past two weeks. In addition, after conducting an ethnographic survey of past studies, the researchers revealed that college students may be at greater risk than other people in the same age group due to the following reasons:
  • 43.2 percent of college students binge drank at least once in the following year while 39.8 percent of same-age noncollege participants.
  • 31.4 percent of college students drove under the influence of alcohol in the last year while only 23.7 percent of those same-age noncollege participants did so.
Since undergraduate college students tend to exhibit higher rates of drinking, alcohol abuse, and related high-risk behavior, university and public health officials have designed and implemented interventions to prevent as well as stop alcohol abuse among college students.

Usefulness of Brief Interventions


Brief interventions have been shown to be successful among the general population. In a meta-analysis of brief interventions, which includes face-to-face contact with a health care provider or educator for people suffering from alcohol abuse, a significant positive impact was found to be present on subjects’ drinking patterns (Moyer, Finney, Swearingen, &Vergun, 2001). However, brief interventions were not more effective than controlled interventions where individuals with severe alcohol abuse problems were included and a single session of advice was not found to be useful for patients with severe drinking problems (ibid). This information is encouraging in terms of the possible success of online interventions to prevent and intervene when low to moderate alcohol abuse is present. Online interventions are brief in nature and are designed to inform the participant of the possible problem. The program can also help them identify ways to drink moderately or abstain from alcohol consumption.

The Nature of Online Alcohol Abuse Interventions

Several online interventions exist that are specifically geared towards college students. These include websites such as MyStudentBody.com and College Alc, whose effectiveness has been reviewed in peer-review journals. These programs must be bought by participating universities, and students are then given access to the websites. One advantage of this is that they are tailored specifically for college students, but they are not available to the general public.

Chiauzzi, et al. (2005) analyzed the effectiveness of www.MyStudentBody.com: Alcohol that provides primary intervention about risks associated with drinking and a self-evaluation based on the BASICS model. The self-evaluation helps to tailor the website to content so that it is appropriate for each individual. Chiauzzi, et al. (2005) found that students who came in at the pre-contemplation stage reduced their consumption of alcohol at a significantly larger proportion than low-motivation to change drinkers. This program can be used to raise awareness among college students who never considered the serious consequences of alcohol consumption or thought about how their personal consumption may be affecting their academics, health, and social interactions. At follow-up, MyStudentBody.com was shown to reduce rates of drinking are a greater rate that the control group which students visited websites that contained information about the risks of drinking once a week for four weeks (ibid).

College Alc or www.preventionstrategies.com is another website that has been tested in a semi-experimental setting. This program allows colleges to customize the website for their students. The prevention strategy focuses on identifying alcohol abuse and its consequences as well as environmental factors, like the college’s policies, and law enforcement, and social situations, that may contribute to excessive alcohol consumption. College Alc reduced participants’ self-reported rates of heavy drinking, experiences of drunkenness, and negative alcohol-related consequences in the last 30 days, but the affect was relatively small (Bersamin, Paschall, Fearnow-Kenney, & Wyrick, 2007). No effect was found on students who did not consume alcohol before entering the program (ibid).

Some websites not geared specifically towards students include a very similar pattern to these programs: a self-assessments and followed bypersonalized feedback about drinking patters. A good example of this type of website is: http://notes.camh.net/efeed.nsf/newform. This website is put together by the Center for Addiction and Mental Health. After completing a self-assessment, each user is given information on how drinking impacts such as the amount money spent buying alcohol, time spent intoxicated and calories consumed over the last year. Also, the website includes a personalized estimate of the likelihood of injury and other negative consequences based on the individual’s drinking habits. Cunningham, Humphreys, Koski-Jannes and Cordingley (2005) conducted a small study on the effectiveness of this website to reduce high risk drinking. They found that alone the website did reduce high risk drinking, but in conjunction with written materials, the intervention was more successful. When colleges use online alcohol prevention and intervention programs, handing out additional materials may increase the effectiveness of the program and some programs, such as College Alc, do offer textbooks and other materials to supplement their website.

Summary of Key Components and Benefits

The Center for Addiction and Mental Health’s assessment, College Alc and MyStudentBody.com all contain key components which should be present in an alcohol abuse prevention and intervention program. These key components are:
  • Assessment of individual’s current drinking patterns
  • Summary or specialized feedback based on assessment
  • Identification of risks associated with drinking and possible environmental influences
These can be important tools in helping students find motivation to cut back on drinking. Some advantages of online programs are that they can reach a large number of students, provide individual feedback, and have been shown to reduce drinking rates. Students also may be more likely to be honest about their drinking patterns in an anonymous, private setting than in a classroom or health care setting. These programs however are not appropriate for those who meet the clinical definition of an alcoholic and these are often the people who suffer the most serious consequences of alcohol consumption. Also, the startup cost of the individualized programs for college students can be expensive and these programs may not address the individual’s complex psychosocial reasons for abusing alcohol. Overall, these interventions seem to be important tools in helping to prevent and curb binge drinking on college campuses.

Additional Websites:
Academic Resources:
Bearsamin M., Paschall, M. J., Fearnow-Kenney, M., & Wyrick, D. (2007). Effectiveness of a web-based
alcohol-misuse and harm-prevention course among high- and low-risk students. Journal of American College Health. 55(4): 247-254.
Chiauzzi, E., Green, T. C., Lord, S., Thum, C., & Goldstein, M. (2005). My student body: A high-risk drinking prevention web site for college students. Journal of American College Health. 53(6): 263-274.
Cunningham, J. A., Humphreys, K., Koski-Jannes, A., & Cordingley, J. (2005). Internet and paper self-help materials for problem drinking: Is there an additive effect? Addictive Behaviors. 30(8):1517-1523. Retrieved November 20, 2007 from doi:10.1016/j.addbeh.2005.03.003.
Hingston, R., Heeren, T., Winter, M., & Wechsler, H. (2005). Magnitude of Alcohol-Related Mortality and Morbidity
Among U.S. College Students: Changes from 1998 to 2001. Annual Review of Public Health. 26:259-79.
Moyer, A., Finney, J. W., Swearingen, C. E., & Vergun, P. (2001). Brief interventions for alcohol problems: A
meta-analytic review of controlled investigations in treatment-seeking and non-treatment-seeking populations.
Addictions. 97: 279-292.
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Teens Divulge Risky Behavior on Social Networking Sites

Teens Divulge Risky Behavior on Social Networking Sites
But e-mail intervention may spur some adolescents to change, study finds
Posted January 6, 2009

By Serena Gordon
HealthDay Reporter
 
MONDAY, Jan. 5 (HealthDay News) -- More than half of teens who use the social networking site MySpace have posted information about sexual behavior, substance abuse or violence, new research shows.
 
The good news, according to a second study from the same research group, is that a simple intervention -- in this case, an-e-mail from a physician -- made some of the teens change their risky behaviors.
 
"I was surprised, at least to some extent, at how clearly teens were discussing behaviors that we struggle to get out of them," said Dr. Megan Moreno, an assistant professor of pediatrics at the University of Wisconsin-Madison.
 
"Once we started getting the findings, we wondered, why are they doing this?" Moreno said. "Do they not get it? And, if they don't understand that this is public, can we send them a cautionary message to let them know just how public their information really is?" Moreno was working at the University of Washington and Seattle Children's Research Institute at the time the studies were done.
 
"We need to devise ways to teach teens and their parents to use the Internet responsibly," study senior author Dr. Dimitri Christakis, director of the Center for Child Health, Behavior and Development at Seattle Children's Research Institute, said in a statement.
 
Results from the two studies appear in the January issue of the Archives of Pediatric and Adolescent Medicine.
 
More than 90 percent of teens in the United States have access to the Internet, according to background information from the studies. About half of all teens who use the Internet also use social networking sites, such as MySpace and Facebook. MySpace boasts more than 200 million profiles, according to the studies, and about one-quarter of those belong to teens under 18.
 
Moreno and her colleagues randomly selected 500 MySpace profiles from people who reported their age as 18. They collected the information during the summer of 2007.
 
They found that 54 percent of the profiles contained information on risky behaviors, with 24 percent referencing sexual behaviors, 41 percent referring to substance abuse and 14 percent posting violent information.
 
Factors associated with a decreased risk of posting risky behaviors included displaying religious involvement or involvement with sports or hobbies.
 
For the second study, the researchers randomly selected 190 profiles of people between 18 and 20 who displayed risky behaviors, such as sexual information. Half were sent an e-mail from a physician that pointed out that the physician had noticed risky behavior on their profile and suggested changing the displayed information. The e-mail message also provided information on where to be tested for sexually transmitted diseases.
 
Almost 14 percent of those who got the e-mail deleted references to sexual behavior, compared with 5 percent of the others.
 
"This was a creative and unique way to reach kids," said Kimberly Mitchell, the author of an accompanying editorial in the same issue of the journal and a research professor at the Crimes Against Children Research Center at the University of New Hampshire in Durham.
 
Mitchell advised parents not to try to forbid their children from using these sites altogether. "It's important for parents to understand how important these social networking sites are to kids," she said. "They're here to stay, and they're not all evil. There can be some really positive aspects to these sites. But adolescents aren't necessarily thinking 10 years ahead, when employers or college administrators may look at these sites. Teens live in the here and now, so parents need to talk to kids about the longer-term impacts and help them think through some of the repercussions."
 
Moreno suggested that parents ask teens to show them their MySpace or Facebook pages. "Teens will definitely balk, but they balk at lots of things, like curfews," she said. "Some parents feel it's a violation of privacy, like reading a diary, but it's out there, it's public."
 
Parents should use this information as a conversation starter, Moreno suggested.
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Study: Social networks can have impact on health behavior

Study: Social networks can have impact on health behavior

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Pharma's Facebook

Pharma's Facebook

Research 2.0: How drug companies are using social networks to recruit
patients for clinical research.

Sarah Kliff

Newsweek Web Exclusive

Like most social-networking sites, Inspire.com is a place where users
talk about the most intimate details of their lives. They want advice on
coping with stage III cancer or to offer encouragement to a mother
deciding about life support for her premature baby. But Inspire's nearly
100,000 users aren't just sharing with each other (and the 62 nonprofits
who partner with the site), they're also receiving targeted information
from pharmaceutical companies who use the site as a recruiting tool for
drug studies. Opening this door between patients and drugmakers has some
obvious benefits but also raises a host of ethical and medical dilemmas.

On the plus side, those grappling with serious or chronic diseases get
to hear about clinical studies and new treatments that they might not
otherwise know about. Pharmaceutical companies get easy online access to
highly engaged populations with specific medical conditions. "One day we
come to you and say, 'There's a clinical trial going on, here's some
information, now it's your decision.' It lets the patients raise their
hand and say, 'I want to participate'," says Inspire's founder, Brian
Loew. Social networks not only allow pharmaceutical companies to hone in
on extremely specific populations, but also enable them to reach
patients who live far from major medical centers and typically never
hear about studies.

Recruitment has long been a bottleneck in medical research. Of the
approximately 50,000 clinical trials currently underway in the United
States, 80 percent are delayed at least a month because of low
enrollment. One problem: potential trial participants are often
skeptical and worried about safety. "There's an increasing wariness
about the pharmaceutical industry and the clinical trial process," says
Ken Kaitlin, director of the Center for the Study of Drug Development at
Tufts University in Boston. "It's not uncommon to hear about drugs taken
off the market because of major safety problems ... that makes the
public a little more concerned." Pharmaceuticals hope they can overcome
such fears by building partnerships with social networks that they can
mine for potential volunteers.

Loew launched Inspire in 2005, and spent the first three years building
up members in partnership with nonprofits, including The Lung Cancer
Alliance and National Organization for Rare Disorders. Now, with a core
group of users on the site, two major pharmaceuticals have begun
recruiting for clinical trials, one in the lung-cancer community and one
in arthritis. Inspire has partnerships with two other major
pharmaceuticals in the works. The drug companies pay Inspire a flat fee
for the recruiting service; the Web site's compensation does not hinge
on meeting a particular recruiting goal.

Three of the four pharmaceuticals working with Inspire declined to
discuss their interest in social networks, or even reveal their names.
The fourth, Merck, declined multiple requests for an interview but did
issue a brief statement on their commitment to "rapid and effective
enrollment of appropriate patients into trials" as to allow for "timely
development of innovative medicines."

Novartis, one of the first drugmakers to engage research participants
through a social network, partnered with PatientsLikeMe.com to recruit
clinical-trial subjects for a multiple-sclerosis drug in 2008. "[Social
networking] hadn't been applied to clinical trials," saysTrevor Mundel,
head of exploratory clinical development at Novartis. "At the time, we
were having a lot of difficulty enrolling patients."

In May 2008, the site sent out a message to the 8,000 members of their
multiple-sclerosis community, alerting them to the Novartis trial. From
that e-mail, nearly 1,500 members visited the Novartis Web site. After
recruiting through PatientsLikeMe.com, Novartis saw a boost in
registrations for the study, although they did not track which or how
many individuals enrolled because of the campaign-due to patient privacy
concerns. "The registration did start to pick up," says Mundel. "We
don't have the tracking, but I've got to believe some of it was
generated by the e-mails."

Nonprofits and government agencies remain hesitant about recruiting on
social networks because they see them as a relatively untested medium.
TrialCheck, a database of both private and public cancer studies, is
interested in using social networks, but is holding off until they have
more information. "Cancer patients should know all of their treatment
options, not just a select few trials that are promoted," says Dianne
Colaizzi, spokesperson for the Coalition of Cancer Cooperative Groups.
"Another issue is how do patients discern the quality of the information
they find on social-networking sites? Many of the sites lack high
quality medical information from trusted sources."

Another problem: the reliability of data that comes from trials where
the participants may be communicating with each other. That doesn't
usually happen in medical studies. But if your study subjects are on the
same social-networking group, what's to stop people from swapping enough
information to figure out which of them is on the real medication vs.
the placebo, essentially "unblinding" the study?

"If you know what to expect because you're going online and seeing
what's happening [with other patients], the result is that the data
could come out biased," says Paul Bleicher, the CEO of a health-tech
startup in Cambridge, Mass., who has written on the role of social
networks in medicine. He doesn't think that pharmaceutical companies
have yet thought through these issues. Novartis's Mundel admits they
haven't figured it all out yet. "It's something which hasn't been worked
through, how [social networks] might worsen the accuracy of
adverse-event reporting," he says. "That's one concern we have to think
about and still don't totally understand."

Despite these drawbacks, clinical-trial recruitment on social networks
is expected to increase. Inspire says that it is signing up 100 new
members a week. As Bleicher writes in a recent article in Applied
Clinical Research, "Technology is here to stay, and it will bring
changes in communication and interactivity that we can't even
anticipate, along with many opportunities and some risk."

But as with all things Web, when things go right, the power of
connecting people is formidable. Take Susan Love's Army of Women, a site
that launched in November 2008 to solicit volunteers for preventative
breast-cancer research. The site capitalized on the
grassroots-organizing powers of the Internet and, largely through
members inviting friends, has amassed more than a quarter million
members that researchers can recruit for research exploring potential
risk factors for breast cancer.

The site is not a social network (although that may come soon), but does
take advantage of many innovative Web 2.0 tools, like blogs written by
researchers describing their study and how Army of Women members are
having an impact. But even if Army of Women does become a social
network, they're operating to collect information for prevention, not
testing the effectiveness of drugs on various conditions, so they're
less likely to run into problems where data is compromised by the
interaction of patients.

Perhaps most important, this site has been able to reach hard-to-find
but willing research participants including Theresa Passerelli. The
60-year-old hospital accountant lives in Warm Springs, a tiny town in
central Georgia with no stoplights or grocery stores. She's 70 miles
from a major medical center, but is participating in important
breast-cancer research on sisters of women with breast cancer. "You have
the walkathons, but those don't advance science," says Passerelli. "When
I saw the Army of Women, I was more than willing to give them my body
and let them do whatever, if there's a possibility there will be some
kind of breakthrough."

URL: http://www.newsweek.com/id/187882

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Tuesday, March 10, 2009

Nielsen: Social Nets Overtake E-mail

Nielsen: Social Nets Overtake E-mail


As online paradigm shifts, advertisers must find a way to add value,
rather than follow the 'push' model


March 9, 2009

-By Brian Morrissey
<http://www.adweek.com/aw/content_display/news/digital/mailto:bmorrissey
@adweek.com>

NEW YORK Social networking has overtaken e-mail as the most popular
Internet activity, according to a new study
<http://blog.nielsen.com/nielsenwire/wp-content/uploads/2009/03/nielsen_
globalfaces_mar09.pdf
> released by Nielsen.

Active reach in what Nielsen defines as "member communities" now exceeds
e-mail participation by 67 percent to 65 percent. What's more, the reach
of social networking and blogging venues is growing at twice the rate of
other large drivers of Internet use such as portals, e-mail and search.

Nielsen, which is the parent company of Adweek, concluded that the shift
to social activity online would have profound effects on marketers and
publishers. For publishers, social networks are eating into time spent
with other online activities, according to Nielsen. For advertisers, the
phenomenon at this stage represents mostly unfulfilled promise for a
deeper connection with consumers who are more difficult to reach in
social environments.

The rise of social media coincides with the decline of portals. Social
networking appears to be snatching away users' online time formerly
spent with e-mail, traditionally a large draw to portals. Such
fragmentation is decreasing portals' importance to advertisers. In a
separate report, top digital shop Razorfish said its spending at portals
declined from 24 percent in 2006 to 16 percent in 2008.

Nielsen found that two-thirds of the world's Internet users visited a
social networking site in 2008. All told, social media now accounts for
almost 10 percent of Internet time. Facebook is leading the pack
worldwide, with monthly visits by three out of 10 Internet users in nine
global markets, per Nielsen.

The growth in social media is not confined to the U.S. Nielsen charted
comparable or higher growth for Australia, Spain, Italy and the United
Kingdom.

Yet for now, user growth at social sites is outpacing advertising
increases, per Nielsen. This will likely change, Nielsen said, as models
shift to value engagement over exposure.

"As the online industry matures and the value of online real estate is
increasingly measured by time spent, rather than pages viewed, a
significant shift in advertising revenue from 'traditional' online media
towards social media could be realized -- if the successful ad model can
be found," the report stated.

The search for a workable ad model is even more urgent now that social
media has broken out of the youth demographic, Nielsen found. For
example, Facebook's greatest growth has come from 35-49-year-olds, and
it has added twice as many 50-64-year-olds as those under 18.

Yet advertising and social media to date have mixed like oil and water.
Part of that is a function of social media's communications role --
advertising has typically performed poorly in chat and e-mail. The
larger challenge for advertising is to move from an interruptive role to
joining conversations. That means advertisers need to find ways to add
value to users' experiences, Nielsen found.

"Whatever the successful ad model turns out to be, the messaging will
have to be authentic and humble, and built on the principle of two-way
conversation -- not a push model -- that adds value to the consumer,"
the report said.

http://blog.nielsen.com/nielsenwire/wp-content/uploads/2009/03/nielsen_g
lobalfaces_mar09.pdf

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Monday, March 09, 2009

Web Users Shaping Consumer Opinion

Web Users Shaping Consumer Opinion

source: media post

According to a new report from Netpop Research,  "Media Shifts to Social," the percent of time people spend communicating online has increased 18% since 2006, while time spent on entertainment has declined 29%. The Executive Summary says that Online entertainment is shifting to a small, powerful proportion of social media contributors fueling Web activity through blogs micro-blogs, social media, video and photo sharing.

 Key Findings from the study include data such as:

  • 105 million Americans contribute to social media
  • Social networking has grown 93% since 2006
  • 7 million Americans are "heavy" social media contributors (6+ activities) who connect with 248 people on a ‘one to many' basis in a typical week
  • 54% of micro-bloggers post or "tweet" daily
  • 72% of micro-bloggers under age 18 post or "tweet" daily

The report concludes that market trends and customer opinion are being shaped by end users more rapidly and with greater impact on business than ever before as an entirely new form of leisure develops around talking and sharing, providing opinions and perspectives... and suggests that Websites need to connect directly with users or the users will create their own venues that are harder for companies to track and participate with effectively.

The study includes the differences in use and frequency among younger users, teens and college students, and light, medium and heavy social media users to understand usage habits and motivations. It also describes photo-sharing, video-sharing, micro-blogging, social networking, tagging, wikis, etc. among 20 online communication and social media channels.

Please visit here to access the full report from Netpop Research and view a slide preview

 
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Follow JDRF at the White House on Twitter!

Follow JDRF at the White House on Twitter! 

President Barack Obama will be signing an Executive Order lifting the federal ban on embryonic stem cell research on Monday in a ceremony at the White House.  A few JDRF volunteers and staff will be at the White House to represent the Foundation.

This is a special moment for everyone that has worked so hard over the past decade.  JDRF wants to make sure that, even though everyone that made this moment possible can’t be at the White House, we can get you as close as possible to the Oval Office!

Follow Each Moment on Twitter
We will do this through a website called Twitter.  Twitter is a website that lets you update your friends and family on what you’re up to.  You can also follow others to find out what’s new with them.  JDRF has set-up a Twitter account (JDRFAdvocacy) so you can follow what we’re up to everyday.  You can find out more about how the site works at http://www.twitter.com

Signing-up for a Twitter account is very easy.  Once you’ve provided just a few pieces of information, your personal Twitter page will be all set. 

To follow updates from JDRF’s Larry Soler directly from the White House through our new Twitter account, follow these simple steps:

1. Visit http://www.twitter.com/JDRFAdvocacy and click ‘Join Now’.
2. Provide a few pieces of information for your Twitter page.
3. You’re all set!  Larry’s updates will begin in the morning before the event begins, during the event, and through the post-event receptions.
4. Forward this to a friend.

Thank you again.  See you from the Oval Office!


 

 
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Breaking News: Merck to Buy Schering-Plough in $41.1 Billion Cash, Stock Deal

New Jersey-based drug makers Merck & Co. and Schering-Plough Corp. announced plans to combine in a $41.1 billion cash-and-stock deal that comes six weeks after rivals Pfizer Inc. and Wyeth unveiled their engagement.

The announcements come as the world's biggest pharmaceutical companies face a litany of pressures -- from product pipelines that likely won't be able to offset companies' blockbusters that will lose patent protection in the coming years to the potential of increased government pressure to lower prices. Merck and Schering-Plough already had a relationship through their cholesterol-drug joint venture, which has seen its sales slump.

"The combined company will benefit from a formidable research and development pipeline, a significantly broader portfolio of medicines and an expanded presence in key international markets, particularly in high-growth emerging markets," Merck Chairman and Chief Executive Richard T. Clark said in a joint press release. (Read the companies' statement.)

In discussing Merck's quarterly earnings last month, Mr. Clark had said the drug maker was open to buying a big rival, signaling a shift for a company that long maintained its research prowess was enough to keep it growing.

Mr. Clark would oversee the combined company, which will retain the Merck name. Three Schering-Plough board members would join Merck's board. Schering-Plough Chairman and Chief Executive Fred Hassan said he "intends to participate in the integration planning until the close."

In an interview, Mr. Clark said the integration is expected to result in a work-force reduction of about 15%, with a high percentage of the job eliminations happening outside the U.S.

Merck, of Whitehouse Station, N.J., has about 55,200 employees world-wide, with 28,000 in the U.S., according to a regulatory filing. Kenilworth, N.J.-based Schering-Plough has about 51,000 global employees, with just 15,000 in the U.S.

Both companies had been laying off employees even before the acquisition deal was struck. Like other major drug makers, they have been contending with lackluster sales growth, hurt by competition from generic drug makers and now the economic downturn.

"Of course when the market is in a mood of desolation, this is often the best time to effect a merger or acquisition," said David Buik of BGC Partners. He added the deal "seems to make huge sense with a cost-cutting exercise imperative, with the Obama administration hell bent on giving the drug companies a very hard time, offering the generic operators a brilliant opportunity."

Some $3.5 billion a year in cost savings are anticipated beyond 2011. Schering-Plough is expected to "modestly" add to Merck's earnings, excluding charges related to the deal, in the first year after its completion and "significantly" thereafter.

Under the deal, Schering-Plough shareholders would get 0.5767 share of Merck and $10.50 in cash for each share they own. That values Schering-Plough at $23.61 a share, a 34% premium to Friday's closing price. Merck shareholders would own 68% of the combined company.

In premarket trading, Schering-Plough jumped 18% to $20.80 while Merck fell 4.4% to $21.75. Mr. Buik noted that Schering-Plough shares advanced nearly 10% in a Friday afternoon rally.

Some 44% of the deal will be cash, with $9.8 billion coming from existing balances and $8.5 billion from committed financing from J.P. Morgan Chase & Co. Merck said its board is committed to keeping its dividend at current levels, which is triple the payment Schering-Plough holders now get. Merck's vow contrasts with Pfizer, which will halve its dividend, the yield of which had been the highest of the major drug makers.

Pfizer's deal for Wyeth, valued at $68 billion when it was unveiled in January, represents the largest takeover in the pharmaceutical sector since Glaxo Wellcome PLC acquired SmithKline Beecham PLC for $76 billion in 2000.

The two companies' cholesterol-drug joint venture has been under pressure for a year following an early 2008 study raised questions about the effectiveness of Zetia. The results sent prescriptions of Zetia and sister drug Vytorin, which combines Zetia with Merck's Zocor, plummeting.

Mr. Hassan took over Schering-Plough six years ago as chairman and CEO at a time when the company has dealt with manufacturing troubles which led to a $500 million fine. At the time, it was said taking over Schering-Plough would test his mettle as a turnaround expert.

Now while the company is in stronger financial shape, its stock sits at the same level it did when Mr. Hassan took charge amid 50% price drop the past 18 months.

Write to Kevin Kingsbury at kevin.kingsbury@dowjones.com

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